♥1: Deletions of WT1, located on chromosome 11p13, are found in patients with aniridia and Wilms' tumor. (Aniridia is caused by an abnormality of the PAX6 gene located adjacent to the WT1 gene). Mutations of WT1 occur in Deny Drash Syndrome.
♥2: A second Wilms' tumor gene, WT2, has been identified on chromosome 11p15 and is associated with BWS.
♥3: Familial Wilm's tumor- Familial cases have an earlier age of onset and an increased frequency of bilateral disease. Two familial Wilms' tumor genes have been localized. FWT1 is located at 17q12-q21 and FWT2 at 19q13.3: LOH for chromosomes 1p and 16q is associated with an increased risk for relapse and death in Wilms' tumor patients
♥2: A second Wilms' tumor gene, WT2, has been identified on chromosome 11p15 and is associated with BWS.
♥3: Familial Wilm's tumor- Familial cases have an earlier age of onset and an increased frequency of bilateral disease. Two familial Wilms' tumor genes have been localized. FWT1 is located at 17q12-q21 and FWT2 at 19q13.3: LOH for chromosomes 1p and 16q is associated with an increased risk for relapse and death in Wilms' tumor patients
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